01 - Heat a large skillet over medium-high heat. Add the ground beef, salt, pepper, smoked paprika, and garlic powder. Break up the meat and stir occasionally until browned and cooked through, approximately 7–8 minutes. Drain excess fat if needed.
02 - While the beef cooks, whisk together the mayonnaise, ketchup, mustard, pickle relish, apple cider vinegar, smoked paprika, salt, and pepper in a small bowl until thoroughly combined. Set aside.
03 - Divide the chopped romaine lettuce evenly among four large serving bowls. Arrange equal portions of the cooked ground beef, cherry tomatoes, shredded cheddar cheese, red onion, pickle slices, and diced avocado on top of each bed of lettuce.
04 - Drizzle each bowl generously with the prepared burger sauce immediately before serving. Enjoy while fresh.